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Human CellExp™ Fc gamma RIV / CD16-2, Mouse recombinant

Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a.
Catalog #: P1426
SKU-Size Size Price Qty
P1426-10 10 µg
$195.00
P1426-50 50 µg
$395.00
More Sizes Get Quote

Product Details

Alternate Name Fc gamma RIV, CD16-2, Fcgr4
Gene Symbol Fcgr4
Gene ID 246256
Accession # A0A0B4J1G0
Source HEK 293 Cells
Appearance Lyophilized powder
Physical Form Description Lyophilized powder
Molecular Weight This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.8 kDa. The protein migrates as 28-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity by SDS-PAGE >90%
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Amino Acid Sequence AA Gly 21 - Gln 203
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

FcgR4 (Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma. Also acts as a receptor for the Fc region of immunoglobulin epsilon. Binds with intermediate affinity to both IgG2a and IgG2b. Does not display binding to IgG1 or IgG3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions.


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