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Human CellExp™ Fc gamma RIIIB /CD16b, human recombinant

Involved in activation of the NK cells for Antibody-Dependent Cell-mediated Cytotoxicity (ADCC)
Catalog #: 7446

In stock

SKU-Size Size Price Qty
7446-10 10 μg
$180.00
7446-50 50 μg
$595.00
More Sizes Get Quote

Product Details

Alternate Name FCGR3B, CD16B, FCG3B, FCGR3, FCG3, IGFR3
Gene Symbol FCGR3B
Gene ID 2215
Accession # O75015
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered PBS (pH 7.4) with 5% trehalose.
Molecular Weight This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 22 kDa. The predicted N-terminus is Gly 17. DTT-reduced Protein migrates as 38-50 kDa due to glycosylation.
Purity by SDS-PAGE ≥98%
Biological Activity Measured by its binding ability in a functional ELISA.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner. CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16b, also known as FCGR3B and FCG3B, is expressed specifically by neutrophils and stimulated eosinophils. CD16b is the low affinity receptor for the Fc region of immunoglobulins gamma. It binds complexed or aggregated IgG and also monomeric IgG. CD16b by itself is not capable of mediating antibody-dependent cytotoxicity and phagocytosis and cannot transduce signals from outside to inside the cell but may do so by associating with cell-specific components. Soluble CD16b has a regulatory role in inflammatory processes and induces the production of pro-inflammatory cytokines.


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