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Human CellExp™ Erythropoietin Receptor

Mediates erythropoietin-induced erythroblast proliferation and differentiation
Catalog #: P1638
SKU-Size Size Price Qty
P1638-20 20 μg
$265.00
P1638-50 50 μg
$455.00
More Sizes Get Quote

Product Details

Alternate Name EPOR, EPO-R
Gene ID 2057
Accession # P19235, NP_000112.1
Source HEK293 cells
Appearance Lyophilized
Molecular Weight The protein migrates as a band at ~55-60 kDa band in SDS-PAGE.
Purity by SDS-PAGE ≥ 95%
Endotoxin Level < 0.1 EU/μg of the protein as determined by LAL method
Biological Activity Measured by its ability to inhibit Epo-dependent proliferation of TF-1 human erythroleukemic cells. The ED₅₀ for this effect is 60-300 ng/ml in the presence of 0.2 U/ml of Recombinant Human EPO Receptor/EPOR.
Reconstitution Instructions Reconstitute to a concentration of 0.1-0.5 mg/ml using sterile distilled water
Amino Acid Sequence The target protein is expressed with the sequence (Ala25-Pro250) of human Erythropoietin Receptor protein fused to Fc and 6×His tag at the C-terminus.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Erythropoietin Receptor is a member of the cytokine receptor family. It mediates erythropoietin-induced erythroblast proliferation and differentiation, activation of Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor plays a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis.


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