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Human CellExp™ HER3 / ErbB3 Extracellular Domain (ED), Human Recombinant

Involved in pathways leading to cell proliferation or differentiation.
Catalog #: 7400
SKU-Size Size Price Qty
7400-10 10 μg
$180.00
7400-50 50 μg
$595.00
7400-250 250 μg
$2,095.00
More Sizes Get Quote

Product Details

Alternate Name ERBB3, ErbB-3, HER3, HER-3, LCCS2, MDA-BF-1, MGC88033, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, Receptor tyrosine-protein kinase erbB-3
Gene Symbol ErbB3
Gene ID 2065
Accession # P21860
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered PBS (pH 7.4)
Molecular Weight This protein is fused with polyhistidine tag at the C-terminus and has a calculated MW of ~70 kDa (20 – 643 aa). Under reducing conditions the protein migrates to ~93 kDa in SDS-PAGE due to glycosylation.
Purity by SDS-PAGE ≥95%
Endotoxin Level <1 EU/μg by LAL method
Biological Activity HER3-biotin can bind immmobilized Human Her2 (ED) (Cat. No. P1160 at 5 μg/ml (100 μl/well)) with a linear range of 0.05-5 μg/ml.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in distilled water to a concentration up to 0.2 mg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

ErbB3, also called human epidermal growth factor receptor 3 (HER3), is a type I membrane glycoprotein and a member of the ErbB family. ErbB family members serve as receptors for the epidermal growth factors (EGF). ErbB3 is expressed in normal adult human gastrointestinal tract, reproductive system, skin, nervous system, urinary tract, and endocrine system. ErbB3 is the only member with a defective kinase domain among ErbB family members. However, ErbB3 can form heterodimers with ErbB2 to complement a high affinity receptor complex. ErbB3 has been shown to bind the ligands heregulin and NRG-2. The lethal congenital contracture syndrome 2 (LCCS2) disease is caused by mutations affecting ErbB3. ErbB3 null mouse embryos show severely underdeveloped atrioventricular valves, leading to death at embryonic day 13.5.


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