Product Details
| Cat # +Size | 7402-10 |
|---|---|
| Size | 10 μg |
| Alternate Name | EGFR, ERBB, ERBB1, HER1, PIG61, mENA |
| Gene Symbol | EGFR |
| Gene ID | 13649 |
| Accession # | Q01279 |
| Source | HEK293 cells |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization. |
| Molecular Weight | This protein has a C-terminal 6×His tag and has a calculated MW of 70 kDa. The predicted N-terminus is Leu 25. In DTT-reduced SDS-PAGE, protein migrates as 110-115 kDa. |
| Purity by SDS-PAGE | ≥95% |
| Endotoxin Level | <1 EU/μg by LAL method |
| Biological Activity | Measured by its binding ability in a functional ELISA. Immobilized mouse EGF at 10 μg/ml can bind mouse EGFR with a linear range of 2.5–1000 ng/ml. |
| Reconstitution Instructions | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
The epidermal growth factor receptor (EGFR; ErbB-1; HER1) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.
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