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Human CellExp™ EphA7 / EHK3 (Active), Human Recombinant

Implicated in mediating nervous system development
Catalog #: P1727
SKU-Size Size Price Qty
P1727-10 10 µg
$225.00
P1727-50 50 µg
$395.00
More Sizes Get Quote

Product Details

Alternate Name EPH Receptor A7; HEK11; Ephrin Type-A Receptor 7; EHK-3; EK11
Gene ID 2045
Accession # Q15375
Source Human Cells
Appearance Lyophilized protein
Physical Form Description Lyophilized powder
Molecular Weight 60.19 kDa predicted, 72 kDa observed
Purity by SDS-PAGE > 95%
Formulation Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2
Endotoxin Level < 1.0 EU per µg as determined by the LAL method
Activity Immobilized Human EphA7-His at 2 μg/ml (100 μl/well) can bind Human EFNA4-Fc-6His. The ED50 of Human EphA7-His is 1.5190 μg/ml
Amino Acid Sequence Gln 28 to Ile 556 with C-terminal 6xHis Tag
Handling Centrifuge the vial prior to opening.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The Ephrin Type-A Receptor 7 is a member of the ephrin receptor subfamily of protein-tyrosine kinases, which are implicated in mediating nervous system development. EphA7 binds to membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-depending bidirectional signaling between the neighboring cells. Interaction between EphA7 and its ligand EFNA5 regulates brain development through the modulation of cell-cell adhesion and repulsion. EphA7 has a repellent activity on axons, and may also regulate brain development through a Caspase-3-dependent proapoptotic mechanism. Overexpression of EphA7 is associated with multiple forms of carcinoma.


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