Human CellExp™ DLL4, Mouse Recombinant

Activates the Notch-1 and Notch-2 receptors
Catalog #: P1163 | abID:

Product Details

Alternate Name Delta-like Protein 4, Delta 4
Gene Symbol Dll4
Gene ID 54485
Accession # Q9JI71
Source HEK 293 cells
Appearance Liquid
Physical Form Description 0.2 μm-filtered solution in PBS
Molecular Weight 95 kDa
Purity by > 90%
Endotoxin Level < 1.0 EU per/μg
Biological Activity Inhibits adipogenesis of 3T3L-1 cells
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, pro-moting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.

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