Product Details
| Alternate Name | Delta-like Protein 4, Delta 4 |
|---|---|
| Gene Symbol | Dll4 |
| Gene ID | 54485 |
| Accession # | Q9JI71 |
| Source | HEK 293 cells |
| Appearance | Liquid |
| Physical Form Description | 0.2 μm-filtered solution in PBS |
| Molecular Weight | 95 kDa |
| Purity by | > 90% |
| Endotoxin Level | < 1.0 EU per/μg |
| Biological Activity | Inhibits adipogenesis of 3T3L-1 cells |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, pro-moting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
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