Product Details
| abID | ab213523 |
|---|---|
| Cat # +Size | P1166-10 |
| Size | 10 μg |
| Alternate Name | Protein Delta Homolog 1, Fetal Antigen 1, Preadipocyte Factor 1, Pref-1, FA1 |
| Gene Symbol | DLK1 |
| Gene ID | 8788 |
| Accession # | P80370 |
| Source | HEK293 cells |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized from PBS + 0.02 % CHAPS |
| Molecular Weight | 65 kDa |
| Purity by | > 98% |
| Endotoxin Level | < 1.0 EU per/μg |
| Biological Activity | Inhibits adipogenesis of 3T3L-1 cells |
| Reconstitution Instructions | Reconstitute with 100 µl sterile water. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The transmembrane and secreted protein delta-like 1 homolog (DLK1; Protein delta homolog 1; Preadipocyte factor 1; Pref-1) belongs to the EGF-like family. It can be cleaved by a tumor necrosis factor-α converting enzyme (TACE) to release a soluble form. DLK1 plays important roles in regulating cell differentiation such as adipogenesis and osteogenesis. Membrane-bound DLK1 promotes hypertrophic myotube formation, whereas soluble DLK1 inhibits myotube formation. The soluble form of DLK1 inhibits preadipocyte differentiation, while membrane DLK1 represses preadipocyte proliferation. DLK1 is also associated with tumor invasion.
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