Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Human CellExp™ CTLA-4/CD152, mouse recombinant

A protein receptor that downregulates the immune system.
Catalog #: P1081
SKU-Size Size Price Qty
P1081-10 10 µg
$85.00
P1081-50 50 µg
$375.00
More Sizes Get Quote

Product Details

Alternate Name CTLA4, CD152, CELIAC3, GRD4, GSE, ICOS, IDDM12
Gene Symbol CTLA4
Gene ID 12477
Accession # P09793
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
Molecular Weight 41.1 kDa
Purity by SDS-PAGE >95%
Endotoxin Level < 1 EU/μg
Biological Activity Immobilized Mouse B7-1 and B7-2, Fc Tag at 0.2 μg/mL (100 μ L/well) can bind Mouse CTLA-4, mouse IgG2a Fc tag with a linear range of 0.1-3 ng/mL and 0.4-3 ng/mL respectively.
Reconstitution Instructions Reconstitute in sterile deionized water to a concentration of 50 μg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.