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Human CellExp™ CSF1R/CD115, Fc Tag, Human Recombinant,

Plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells.
Catalog #: P1374

In stock

SKU-Size Size Price Qty
P1374-20 20 µg
$105.00
P1374-100 100 µg
$325.00
More Sizes Get Quote

Product Details

Alternate Name CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR
Gene Symbol 1436
Gene ID 1436
Accession # P07333
Source HEK293 cells
Appearance Lyophilized powder
Physical Form Description Liquid
Molecular Weight 80.7 kDa (IgG1 Fc tag at C-terminus)
Purity by SDS-PAGE >95% by SDS-PAGE.
Endotoxin Level Less than 0.1 EU per μg by the LAL method.
Reconstitution Instructions Reconstitute in sterile deionized water to a concentration of 50 μg/ml.
Amino Acid Sequence AA Ile 20 - Glu 512
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.


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