Product Details
| abID | ab286092 |
|---|---|
| Cat # +Size | P1524-10 |
| Size | 10 μg |
| Source | Mammalian Cell |
| Appearance | Sterile Filtered colorless solution |
| Physical Form Description | Liquid |
| Purity by | >95% |
| Amino Acid Sequence | aa 1-674 (Fc tag) |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
SARS-CoV is an enveloped, single and positive-stranded RNA virus. Cell entry of severe acute respiratory syndrome coronavirus (SARS-CoV) is mediated by the viral spike (S) protein. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. For viral entry, the surface unit (S1) of SARS S binds to the cellular receptor angiotensin converting enzyme 2 (ACE2) and the transmembrane unit (S2) then fuses the viral membrane with a host cell membrane. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. Because the S protein of SARS-CoV is involved in receptor recognition, as well as virus attachment and entry, it represents one of the most important targets for the development of SARS vaccines and therapeutics.
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Where is the Fc tag located and what is the origin of the Fc tag?
The Fc tag is located on the C-terminal and the origin is from sheep.
