Human CellExp™ SARS-CoV-2 Spike Protein, Recombinant

Glycoprotein that enables viral entry into the host cell
Catalog #: P1547 | abID: ab286102

Product Details

abID ab286102
Gene Symbol S
Accession # P0DTC2
Source HEK 293 cells
Appearance Liquid protein
Physical Form Description Supplied as a 0.22 μm filtered solution in PBS, pH 7.4.
Molecular Weight 180 kDa (C-terminus His-tag)
Purity by SDS-PAGE >95%
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2 S1+S2 ECD (S-ECD) at 2μg/mL (100 μL/well) can bind recombinant Human ACE2 with a linear range of 0.15-3.72 ng/mL.
Amino Acid Sequence Val11-Gln1208 ( 6×His tag at the C-terminus)
Handling Centrifuge the vial prior to opening.
Storage Conditions -70ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SARS-CoV is an enveloped, single and positive-stranded RNA virus. Cell entry of severe acute respiratory syndrome coronavirus (SARS-CoV) is mediated by the viral spike (S) protein. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. For viral entry, the surface unit (S1) of SARS S binds to the cellular receptor angiotensin-converting enzyme 2 (ACE2) and the transmembrane unit (S2) then fuses the viral membrane with a host cell membrane. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. Because the S protein of SARS-CoV is involved in receptor recognition, as well as virus attachment and entry, it represents one of the most important targets for the development of SARS vaccines and therapeutics.

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