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Human CellExp™ Coronavirus Spike Protein (SARS-CoV-2; RBD), Recombinant

Glycoprotein that enables viral entry into the host cell
Catalog #: P1529
SKU-Size Size Price Qty
P1529-10 10 μg
$145.00
P1529-50 50 μg
$535.00
More Sizes Get Quote

Product Details

Source Mammalian Cells
Appearance Liquid protein
Physical Form Description Liquid
Molecular Weight 51 kDa (Fc-tag)
Purity by >95%
Amino Acid Sequence Peptide composed of 457 amino acids from spike protein receptor binding domain (RBD).
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SARS-CoV is an enveloped, single and positive-stranded RNA virus. Cell entry of severe acute respiratory syndrome coronavirus (SARS-CoV) is mediated by the viral spike (S) protein. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. For viral entry, the surface unit (S1) of SARS S binds to the cellular receptor angiotensin-converting enzyme 2 (ACE2) and the transmembrane unit (S2) then fuses the viral membrane with a host cell membrane. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. Because the S protein of SARS-CoV is involved in receptor recognition, as well as virus attachment and entry, it represents one of the most important targets for the development of SARS vaccines and therapeutics.


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