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Human CellExp™ Complement C5a , Mouse recombinant

a potent chemotactic factor for human peripheral blood neutrophils and monocytes
Catalog #: P1427
SKU-Size Size Price Qty
P1427-10 10 µg
$105.00
P1427-50 50 µg
$395.00
More Sizes Get Quote

Product Details

Alternate Name C5a, Complement Component 5a, Hemolytic complement
Gene Symbol C5
Gene ID 15139
Accession # P06684
Source E.coli
Appearance Lyophilized powder
Physical Form Description Lyophilized powder
Molecular Weight This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 10.9 kDa. The protein migrates as 14 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity by SDS-PAGE >95%
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Amino Acid Sequence AA Asn 679 - Arg 755
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5, is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.


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