Product Details
| Alternate Name | Complement C5; C5; CPAMD4 |
|---|---|
| Accession # | XP_005580972.1 |
| Source | human 293 cells (HEK293) |
| Appearance | Sterile Filtered colorless solution |
| Physical Form Description | Lyophilized |
| Molecular Weight | This protein carries a polyhistidine tag at the C-terminus. The mature form of Complement C5 is a disulfide-linked heterodimer composed of proteolytically cleaved α and β chain. Each α and β chain has a calculated MW of 73.3 kDa (β chain) and 114.9 kDa (α |
| Purity by SDS-PAGE | >95% |
| Endotoxin Level | Less than 1.0 EU per μg by the LAL method |
| Reconstitution Instructions | Reconstitute in sterile deionized water to the desired protein concentration. |
| Amino Acid Sequence | AA Gln 19 - Cys 1676 |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
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