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Human CellExp™ CEACAM1/CD66a, Extracellular Domain (ED), Human Recombinant

Cell adhesion protein that plays role in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
Catalog #: P1245
SKU-Size Size Price Qty
P1245-10 10 μg
$175.00
P1245-50 50 μg
$695.00
More Sizes Get Quote

Product Details

Alternate Name Carcinoembryonic antigen-related cell adhesion molecule 1, BGP, BGP1, BGPI, CD66a, CEACAM‑1, CEACAM1, CEAM1
Gene Symbol CEACAM1
Gene ID 634
Accession # P13688
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS pH 7.4
Molecular Weight 45 kDa
Purity by SDS-PAGE ≥95%
Biological Activity Immobilized Human TIM3 at 5 μg/ml (100 μl/well) can bind to biotinylated CEACAM1 (ED) with a linear range of 0.08-10 µg/ml.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in distilled water.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CEACAM1, also known as biliary glycoprotein I (BGP I) or CD66a, is an extensively studied cell surface molecule with established functions in multiple cancer types, as well as in various compartments of the immune system. The highly glycosylated CEACAM1 contains a 35-428 amino acid extracellular domain (ECD) which includes one N-terminal V-type Ig-like domain, followed by three C2-type Ig-like domains. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic binding, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.


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