Human CellExp™ CD8b, Human Recombinant

Integral membrane glycoprotein that plays an essential role in the immune response
Catalog #: P1244 | abID: ab286050

Product Details

abID ab286050
Alternate Name T cell surface glycoprotein CD8 beta chain, T lymphocyte surface glycoprotein beta chain, CD8b antigen, CD8 antigen beta polypeptide 1 (p37), CD8 beta, CD8b, CD8B_HUMAN, CD8B1, Leu2, Ly3, LYT3, MGC119115, P37
Gene Symbol CD8B
Gene ID 926
Accession # P10966
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS pH 7.4
Molecular Weight 18 kDa
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in distilled water.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


The T-cell surface glycoprotein CD8 beta chain, also called CD8 beta (CD8b), P37 or LEU2 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. It plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Being a member of functional coreceptors, CD8 functions either as a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. In T-cells, CD8b functions primarily as a coreceptor for class I MHC molecules. It initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, CD8b plays a critical role in thymic selection of CD8+ T-cells. CD8b is thought to play a role in the process of T-cell mediated killing.

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