Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

New

Human CellExp™ CD8b, Human Recombinant

Integral membrane glycoprotein that plays an essential role in the immune response
Catalog #: P1244

In stock

SKU-Size Size Price Qty
P1244-10 10 µg
$175.00
P1244-50 50 µg
$695.00
More Sizes Get Quote

Product Details

Alternate Name T cell surface glycoprotein CD8 beta chain, T lymphocyte surface glycoprotein beta chain, CD8b antigen, CD8 antigen beta polypeptide 1 (p37), CD8 beta, CD8b, CD8B_HUMAN, CD8B1, Leu2, Ly3, LYT3, MGC119115, P37
Gene Symbol CD8B
Gene ID 926
Accession # P10966
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS pH 7.4
Molecular Weight 18 kDa
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in distilled water.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The T-cell surface glycoprotein CD8 beta chain, also called CD8 beta (CD8b), P37 or LEU2 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. It plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Being a member of functional coreceptors, CD8 functions either as a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. In T-cells, CD8b functions primarily as a coreceptor for class I MHC molecules. It initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, CD8b plays a critical role in thymic selection of CD8+ T-cells. CD8b is thought to play a role in the process of T-cell mediated killing.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.
$
Subscribe to our Newsletter!!
and automatically get enrolled into a raffle to win Google Home.
Offer valid for US customers only.