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Human CellExp™ CD89 Protein, Human Recombinant

Tumor suppressor
Catalog #: P1642
SKU-Size Size Price Qty
P1642-20 20 μg
$265.00
P1642-50 50 μg
$345.00
More Sizes Get Quote

Product Details

Alternate Name Immunoglobulin Alpha Fc Receptor; IgA Fc receptor; Fc Fragment Of IgA Receptor; CD89; FCAR; CD89 Antigen; FcalphaRI; CTB-61M7.2; FCAR Variant 14
Gene ID 2204
Accession # NP_001991.1; Q13603
Source HEK293 cells
Appearance Sterile Filtered colorless solution
Physical Form Description Solid
Molecular Weight 65-75 kDa
Purity by SDS-PAGE ≥ 97%
Endotoxin Level < 0.1 EU/μg of the protein by LAL method.
Amino Acid Sequence Gln22-Asn227 aa
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin present in the mucosal areas. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play a fundamental role in preventing tumor development and growth, as well as in controlling inflammation.


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