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Human CellExp™ CD58 / LFA-3, Fc Tag, human recombinant

Ligand of T-lymphocyte CD2 glycoprotein
Catalog #: P1150

In stock

SKU-Size Size Price Qty
P1150-10 10 μg
$85.00
P1150-50 50 μg
$365.00
More Sizes Get Quote

Product Details

Alternate Name CD58, LFA3, Ag3
Gene Symbol CD58
Gene ID 965
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.
Molecular Weight 48.1 kDa
Purity by SDS-PAGE > 95%
Endotoxin Level < 1.0 EU per/μg
Biological Activity Immobilized Human CD2, His Tag at 2 μg/mL (100 μL/well) can bind Human CD58, Fc Tag with a linear range of 10-156 ng/mL
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3). CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) [3] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.


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