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Human CellExp™ CD47, Rhesus macaque Recombinant

Plays a role in cell adhesion modulation of integrins
Catalog #: P1241

In stock

$165.00

Product Details

Cat # +Size P1241-10
Size 10 μg
Alternate Name CD47, MER6, IAP, OA3
Gene Symbol CD47
Gene ID 704980
Accession # F7A802
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
Molecular Weight 15.8 kDa
Purity by SDS-PAGE > 95%
Endotoxin Level < 1.0 EU per/μg
Biological Activity Immobilized Human SIRP alpha, Fc Tag at 5 μg/mL (100 μL/well) can bind Cynomolgus / Rhesus macaque CD47, His Tag with a linear range of 4-63 ng/mL
Reconstitution Instructions Reconstitute in sterile deionized water to a concentration of 50 µg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.


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