Product Details
| Alternate Name | CD40LG ,CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39 |
|---|---|
| Gene Symbol | CD40 |
| Gene ID | 21939 |
| Accession # | P27512 |
| Source | HEK 293 cells |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized from 0.22 μm filtered solution in PBS pH 7.4 |
| Molecular Weight | 20.5 kDa |
| Purity by SDS-PAGE | > 95% |
| Reconstitution Instructions | Reconstitute in sterile deionized water to the desired protein concentration. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
CD40, also known as Tumor necrosis factor receptor superfamily member 5 (TNFRSF5), is a 32 kDa cell surface receptor expressed by B-cells, dendritic cells, macrophages and other antigen-presenting cells. CD40 consists of N-terminal extracellular domain and C-terminal transmembrane domain. The mouse CD40 shares 61.2% of sequence identity with human CD40. Interaction between CD40 and CD40L activates antigen-presenting B-cells to produce antibody. CD40 is expressed in multiple cancer cell lines including lymphomas and myeloma.
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