Human CellExp™ CD38, Human Recombinant

Catalog #: P1014 | abID:

Product Details

Alternate Name ADP-ribosyl Cyclase 1, Cyclic ADP-ribose Hydrolase 1, ADPRC 1, T10
Gene Symbol CD38
Gene ID 952
Accession # P28907
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 µm filtered solution in PBS (pH 7.4) with 5% Trehalose
Molecular Weight 56 kDa, calculated (with human Fc Tag fused to C-terminus)
Purity by SDS-PAGE > 95%
Reconstitution Instructions Reconstitute in 1X PBS to the desired protein concentration.
Specific Activity The specific (Cyclase) activity is > 10 mU/mg, as measured under the described conditions using BioVision’s CD38 (Cyclase) Activity Assay Kit (Cat. No. K2042).
Unit Definition One unit is the amount of enzyme that cleaves the substrate nicotinamide guanine dinucleotide (NGD+) and liberates 1 μmol MAP per minute at pH 7.5 and 37 °C
Handling Centrifuge the vial prior to opening.
Storage Conditions Store lyophilized protein at -20 °C. Once reconstituted, aliquot and store at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


CD38, also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications including social amnesia possibly related to autism. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.

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