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Human CellExp™ CD38, human recombinant

Catalog #: P1014
SKU-Size Size Price Qty
P1014-10 10 µg
$145.00
P1014-50 50 µg
$395.00
More Sizes Get Quote

Product Details

Alternate Name ADP-ribosyl Cyclase 1, Cyclic ADP-ribose Hydrolase 1, ADPRC 1, T10
Gene Symbol CD38
Gene ID 952
Accession # P28907
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.2μm-filtered solution in PBS.
Molecular Weight 70 kDa
Purity by SDS-PAGE ≥ 98%
Endotoxin Level < 5 EU/mg
Reconstitution Instructions Reconstitute in 1X PBS to the desired protein concentration.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

CD38, also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications including social amnesia possibly related to autism. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.


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