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Human CellExp™ CD304 / NRP1 / Neurophilin-1, Fc Tag, mouse recombinant

A receptor involved in the development of the cardiovascular system
Catalog #: P1409

In stock

SKU-Size Size Price Qty
P1409-10 10 µg
$105.00
P1409-50 50 µg
$395.00
More Sizes Get Quote

Product Details

Alternate Name NRP1, Neuropilin-1, NRP, VEGF165R, CD304
Gene Symbol Nrp1
Gene ID 18186
Accession # P97333-1
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 120.5 kDa. The protein migrates as 125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity by SDS-PAGE >90%
Endotoxin Level Less than 0.1 EU per μg by the LAL method.
Amino Acid Sequence AA Phe 22 - Pro 856
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.


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