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Human CellExp™ CD30 /TNFRSF8, Fc Tag, Human Recombinant

May play a role in the regulation of cellular growth and transformation of activated lymphoblasts
Catalog #: P1331

In stock

SKU-Size Size Price Qty
P1331-10 10 μg
$85.00
P1331-50 50 μg
$355.00
More Sizes Get Quote

Product Details

Alternate Name TNFRSF8, CD30, D1S166E, Ki-1
Gene Symbol TNFRSF8
Gene ID 943
Accession # P28908
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Molecular Weight 64.6 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level < 1.0 EU per/μg
Biological Activity Immobilized Human CD30 Ligand, Mouse IgG2a Fc Tag, low endotoxin at 5 μg/mL (100 μL/well) can bind Human CD30, Fc Tag with a linear range of 2-20 ng/mL.
Reconstitution Instructions Reconstitute in sterile deionized water to a concentration of 50 μg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Human CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. TNFRSF-8 is expressed by activated, but not by resting, T and B cells. Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15. CD30 is the receptor for TNFSF8/CD30L. CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B. TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.


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