Product Details
| Alternate Name | CD3 delta/epsilon; CD3 d/e; Human CellExp™ CD3 epsilon-CD3 delta Heterodimer; Human CellExp™ CD3 epsilon (His-tag) CD3 delta Heterodimer; Human CellExp™ CD3 epsilon (His-tag) - CD3 delta Heterodimer; Human CellExp™ CD3 delta/epsilon; CD3E & CD3D; CD3 delta & CD3 epsilon; CD3 epsilon (His-tag) - CD3 delta Heterodimer |
|---|---|
| Gene Symbol | CD3E, CD3D |
| Gene ID | 916, 915 |
| Accession # | P07766, P04234 |
| Source | HEK 293 cells |
| Appearance | Lyophilized powder |
| Physical Form Description | Lyophilized |
| Molecular Weight | The calculated MW is 16 kDa (CD3E) and 13 kDa (CD3D) |
| Purity by SDS-PAGE | ≥ 95% |
| Reconstitution Instructions | Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Reconstitute in sterile PBS (pH 7.4). |
| Amino Acid Sequence | Human CD3E (Asp 23 - Asp 126) (6x His-tag at C-Terminal) and CD3D (Phe 22 - Ala 105, no His-tag) |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
T-cell surface glycoprotein CD3 delta & CD3 epsilon chain, also known as CD3D & CD3E or CD3D&CD3E respectively, are single-pass type I membrane proteins. CD3D, together with CD3E, CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta, and gamma/delta heterodimers, form the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Since CD3 is required for T-Cell activation, drugs and therapeutics targeting CD3 are being researched for diseases like Type 1 diabetes and other autoimmune diseases. For example, Muromonab-CD3, a monoclonal antibody targeting the CD3 receptor, is an immunosuppressant drug to reduce acute rejection in patients with organ transplants.
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