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Human CellExp™ CD3 epsilon (His-tag) & CD3 delta Heterodimer

CD3 epsilon (his-tag) and CD3 delta heterodimer important in coupling antigen recognition
Catalog #: P1655
SKU-Size Size Price Qty
P1655-10 10 μg
$180.00
P1655-50 50 μg
$425.00
More Sizes Get Quote

Product Details

Alternate Name CD3 delta/epsilon; CD3 d/e; Human CellExp™ CD3 epsilon-CD3 delta Heterodimer; Human CellExp™ CD3 epsilon (His-tag) CD3 delta Heterodimer; Human CellExp™ CD3 epsilon (His-tag) - CD3 delta Heterodimer; Human CellExp™ CD3 delta/epsilon; CD3E & CD3D; CD3 delta & CD3 epsilon; CD3 epsilon (His-tag) - CD3 delta Heterodimer
Gene Symbol CD3E, CD3D
Gene ID 916, 915
Accession # P07766, P04234
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight The calculated MW is 16 kDa (CD3E) and 13 kDa (CD3D)
Purity by SDS-PAGE ≥ 95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Reconstitute in sterile PBS (pH 7.4).
Amino Acid Sequence Human CD3E (Asp 23 - Asp 126) (6x His-tag at C-Terminal) and CD3D (Phe 22 - Ala 105, no His-tag)
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

T-cell surface glycoprotein CD3 delta & CD3 epsilon chain, also known as CD3D & CD3E or CD3D&CD3E respectively, are single-pass type I membrane proteins. CD3D, together with CD3E, CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta, and gamma/delta heterodimers, form the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Since CD3 is required for T-Cell activation, drugs and therapeutics targeting CD3 are being researched for diseases like Type 1 diabetes and other autoimmune diseases. For example, Muromonab-CD3, a monoclonal antibody targeting the CD3 receptor, is an immunosuppressant drug to reduce acute rejection in patients with organ transplants.


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