Human CellExp™ CD3 epsilon & CD3 delta Heterodimer

CD3 epsilon (Fc-tag) and CD3 delta heterodimer important in coupling antigen recognition
Catalog #: P1183 | abID: ab286041

Product Details

abID ab286041
Cat # +Size P1183-10
Size 10 μg
Alternate Name CD3E & CD3D, CD3 delta & CD3 epsilon, CD3 delta / epsilon
Gene Symbol CD3E, CD3D
Gene ID 916, 915
Accession # P07766, P04234
Source Expi293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 µm filtered solution in PBS (pH 7.4)
Molecular Weight 37.8 kDa and 35.4 kDa
Purity by SDS-PAGE >95%
Endotoxin Level < 1.0 EU per/μg
Biological Activity Human CD3 epsilon & CD3 delta Heterodimer Protein was immobilized at 0.5 µg/ml (100 µl/well). Dose response curve using Anti-hCD3E/CD3D Ab foralumab gave an EC₅₀ of 21.69 ng/ml by ELISA.
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Amino Acid Sequence Human CD3E (Asp 23-Asp 126) and CD3D (Phe 22-Ala 105) (Fc tag at C-terminal)
Handling Centrifuge the vial prior to opening
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

T-cell surface glycoprotein CD3 delta & CD3 epsilon chain, also known as CD3D & CD3E or CD3D&CD3E respectively, are single-pass type I membrane proteins. CD3D, together with CD3- epsilon (CD3E), CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.


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Which protein has the Fc-tag? Is it only CD3 epsilon or only CD3 delta or do both proteins have the Fc-tag?
Each subunit has an Fc tag. But it has a special design, which makes the two Fc bind together.