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Human CellExp™ CD28, Human recombinant

T-cell-specific surface glycoprotein CD28
Catalog #: 9237
SKU-Size Size Price Qty
9237-10 10 µg
$160.00
9237-100 100 µg
$620.00
More Sizes Get Quote

Product Details

Alternate Name CD28, Tp44
Gene Symbol CD28
Gene ID 940
Accession # AAH93698
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH7.4.
Molecular Weight 66-70 kDa
Purity by SDS-PAGE ≥97%
Endotoxin Level < 0.2 EU/μg
Biological Activity Immobilized human CD28 at 2 μg/mL (100 μL/well) can bind human Biotin-B7-1 (CD80) Fc with a linear range of 0.01-0.5 μg/mL when detected by Streptavidin-HRP second antibody.
Reconstitution Instructions Reconstitute in ddH2O or sterile PBS, pH 7.4.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Human CD28 is composed of four exons encoding a protein of 220 amino acids that is expressed on the cell surface as a glycosylated, disulfide-linked homodimer of 44 kDa. Members of the CD28 family share a number of common features. These receptors consist of paired V-set immunoglobulin superfamily (IgSF) domains attached to single transmembrane domains and cytoplasmic domains that contain critical signaling motifs. The CD28 and CTLA4 ligands, CD80 and CD86, consist of single V-set and C1-set IgSF domains. The interaction of these costimulatory receptors with ligands is mediated through the MYPPPY motif within the receptor V-set domains. CD28 is expressed constitutively on almost all human CD4 T cells and approximately 50% of CD8 T cells. CD28 costimulation has diverse effects on T cell function, including biochemical events at the immunological synapse, downstream phosphorylation and other post-translational modifications, transcriptional changes, and cytoskeletal remodeling. At the most basic level, CD28 signals increase a cell’s glycolytic rate, allowing cells to generate the energy necessary for growth and proliferation.


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