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Human CellExp™ CD27 Ligand/ CD70, Human Recombinant

Cytokine that binds to CD27 and plays role in T-cell activation.
Catalog #: P1381

In stock

SKU-Size Size Price Qty
P1381-10 10 µg
$105.00
P1381-50 50 µg
$345.00
More Sizes Get Quote

Product Details

Alternate Name CD70, CD27LG, TNFSF7, TNFSF7G, CD27L
Gene Symbol CD70
Gene ID 970
Accession # P32970
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Purity by SDS-PAGE >90% as determined by SDS-PAGE
Endotoxin Level Less than 1.0 EU per μg by the LAL method
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 µg/ml. Do not vortex. It is recommended to store at -20°C.
Amino Acid Sequence AA Gln 39 - Pro 193
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.


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