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Human CellExp™ CD27 Ligand/ CD70, Fc Tag, Human Recombinant

Cytokine that binds to CD27 and plays role in T-cell activation.
Catalog #: P1366

In stock

SKU-Size Size Price Qty
P1366-20 20 µg
$95.00
P1366-100 100 µg
$345.00
More Sizes Get Quote

Product Details

Alternate Name CD70, CD27LG, TNFSF7, TNFSF7G, CD27L
Gene Symbol CD70
Gene ID 970
Accession # P32970
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.
Molecular Weight 43.6 kDa
Purity by SDS-PAGE >85%
Endotoxin Level <1 EU/μg by LAL method
Biological Activity Immobilized Human CD27, Mouse IgG2a Fc Tag at 2 μg/mL (100 μL/well) can bind Human CD27 Ligand, Fc Tag with a linear range of 0.4-13 ng/mL.
Reconstitution Instructions Reconstitute in sterile deionized water to a concentration of 100 µg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation.


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