Product Details
| Alternate Name | IL2RA, Interleukin-2 receptor subunit alpha, p55, CD25, IL2-RA, TAC antigen |
|---|---|
| Gene Symbol | IL2RA |
| Gene ID | 3559 |
| Accession # | P01589 |
| Source | HEK 293 cells |
| Physical Form Description | Lyophilized from 0.22 μm filtered PBS (pH 7.4) with 5% trehalose. |
| Molecular Weight | This protein is fused to 6x His tag at the C-terminus and has a calculated MW of 26 kDa. The protein behaves as ~55 kDa and ~100 kDa polypeptide under reducing (R) and non-reducing (NR) conditions (SDS-PAGE) due to glycosylation and dimerization. |
| Purity by SDS-PAGE | ≥95% |
| Reconstitution Instructions | Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Interleukin-2 receptor subunit alpha (IL2RA) is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells. IL2RA binds IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covalently with the IL2 receptor beta and gamma chain, and subsequently initiates intracellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been considered as an activation marker. While both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.
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