Human CellExp™ CD25/IL-2R alpha, C-His Tag, Human Recombinant

Extracellular Domain of IL-2R fused to 6x His tag at the C-terminus.
Catalog #: P1303 | abID:

Product Details

Alternate Name IL2RA, Interleukin-2 receptor subunit alpha, p55, CD25, IL2-RA, TAC antigen
Gene Symbol IL2RA
Gene ID 3559
Accession # P01589
Source HEK 293 cells
Physical Form Description Lyophilized from 0.22 μm filtered PBS (pH 7.4) with 5% trehalose.
Molecular Weight This protein is fused to 6x His tag at the C-terminus and has a calculated MW of 26 kDa. The protein behaves as ~55 kDa and ~100 kDa polypeptide under reducing (R) and non-reducing (NR) conditions (SDS-PAGE) due to glycosylation and dimerization.
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Interleukin-2 receptor subunit alpha (IL2RA) is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells. IL2RA binds IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covalently with the IL2 receptor beta and gamma chain, and subsequently initiates intracellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been considered as an activation marker. While both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.