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Human CellExp™ CD25/IL-2R alpha, C-His Tag, Human Recombinant

Extracellular Domain of IL-2R fused to 6x His tag at the C-terminus.
Catalog #: P1303
SKU-Size Size Price Qty
P1303-10 10 μg
$115.00
P1303-50 50 μg
$475.00
P1303-250 250 μg
$1,895.00
P1303-1000 1000 μg
$7,580.00
More Sizes Get Quote

Product Details

Alternate Name IL2RA, Interleukin-2 receptor subunit alpha, p55, CD25, IL2-RA, TAC antigen
Gene Symbol IL2RA
Gene ID 3559
Accession # P01589
Source HEK 293 cells
Physical Form Description Lyophilized from 0.22 μm filtered PBS (pH 7.4) with 5% trehalose.
Molecular Weight This protein is fused to 6x His tag at the C-terminus and has a calculated MW of 26 kDa. The protein behaves as ~55 kDa and ~100 kDa polypeptide under reducing (R) and non-reducing (NR) conditions (SDS-PAGE) due to glycosylation and dimerization.
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Interleukin-2 receptor subunit alpha (IL2RA) is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells. IL2RA binds IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covalently with the IL2 receptor beta and gamma chain, and subsequently initiates intracellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been considered as an activation marker. While both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.


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