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Human CellExp™ CD19, Fc Tag, Rhesus macaque recombinant

B-lymphocyte antigen CD19
Catalog #: P1329

In stock

SKU-Size Size Price Qty
P1329-10 10 µg
$95.00
P1329-50 50 µg
$445.00
More Sizes Get Quote

Product Details

Alternate Name CD19, B4, CVID3, MGC12803
Gene Symbol CD19
Gene ID 705211
Accession # F7F486
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Generally Mannitol or Trehalose is added as a protectant before lyophilization
Molecular Weight 56.7 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level < 1 EU/μg
Reconstitution Instructions Reconstitute in sterile deionized water to a concentration of 50 μg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

B-lymphocyte antigen CD19 (CD19) is also known as B-lymphocyte surface antigen B4, Differentiation antigen CD19 and T-cell surface antigen Leu-12, which is a single-pass type I membrane protein and contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. CD19 interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. CD19 also interacts with PLCG2 when phosphorylated on Tyr-409. CD19 is an important pan B cell marker and co-stimulatory protein in humans and mice. CD19 is a hallmark differentiation antigen of the B cell lineage and positively regulates antigen receptor signal transduction in mature B cells. CD19 defines signaling thresholds for the Ag receptor as well as other cell surface receptors that regulate B lymphocyte selection, activation, and differentiation. Defects in CD19 are a cause of hypogammaglobulinemia.


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