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Human CellExp™ CCL6, mouse recombinant

Induced upon GM-CSF stimulation
Catalog #: 7226
$345.00

Product Details

Cat # +Size 7226-10
Size 10 μg
Alternate Name CCL6, SCYA6, C10, MRP-1
Gene Symbol CCL6
Gene ID 20305
Accession # P27784
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Molecular Weight This protein is fused with a C-terminal 6 × His tag, has a calculated MW of 11.4 kDa expressed. The predicted N-terminus is Gly22. Protein migrates as 14 kDa in reduced SDS-PAGE.
Purity by SDS-PAGE ≥95%
Endotoxin Level < 0.1 ng/μg of protein (<1EU/μg).
Biological Activity Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR1.The ED50 for this effect is typically 0.01-0.15 μg/mL.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Chemokine (C-C motif) ligand 6 (CCL6), a member of the CC chemokine family, was initially identified as a transcript that is induced in bone marrow cells upon stimulation with GM-CSF. CCL6 has only been identified in rodents. A human homologue for mouse CCL6 has not been identified. The mCCL6 cDNA encodes a 116 amino acid residue precursor protein with a hydrophobic signal peptide that is cleaved to yield a 95 amino acid residue mature protein. In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, where it is strongly induced upon GM-CSF stimulation. Mouse CCL6 expression was also shown to be strongly induced by IL-4 in mouse macrophages and by cytokine IL-13 in mouse lung. Mouse CCL6 is located on chromosome 11. The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.


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