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Human CellExp™ Cathepsin S, human recombinant

A lysosomal cysteine protease participating in the degradation of antigenic proteins to peptides
Catalog #: 7277
SKU-Size Size Price Qty
7277-10 10 μg
$275.00
7277-50 50 μg
$970.00
More Sizes Get Quote

Product Details

Alternate Name Cathepsin S, CTSS
Gene Symbol CTSS
Gene ID 1520
Accession # P25774
Source HEK 293 cells
Appearance Liquid
Physical Form Description A 0.2 μM filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5.
Molecular Weight ~ 37 kDa
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Endotoxin Level <1 EU/μg by LAL method
Biological Activity >1000 mU (1U = 1 µmole/min/mg) as determined by Cathepsin S Activity Assay Kit (K144-100).
Amino Acid Sequence QLHKDPTLDHHWHLW KKTYGKQYKEKNEEA VRRLIWEKNLKFVMLH NLEHSMGMHSYDLGM NHLGDMTSEEVMSLM SSLRVPSQWQRNITYK SNPNWILPDSVDWRE KGCVTEVKYQGSCGA CWAFSAVGALEAQLK LKTGKLVSLSAQNLVD CSTEKYGNKGCNGGF MTTAFQYIIDNKGIDSD ASYPYKAMDQKCQYDSK YRAATCSKYTELPYGRED VLKEAVANKGPVSVGVD ARH
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease (AD) and Down Syndrome (DS).


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