Product Details
| abID | ab285804 |
|---|---|
| Alternate Name | Cathepsin S, CTSS |
| Gene Symbol | CTSS |
| Gene ID | 1520 |
| Accession # | P25774 |
| Source | HEK 293 cells |
| Appearance | Liquid |
| Physical Form Description | A 0.2 μM filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5. |
| Molecular Weight | ~ 37 kDa |
| Purity by SDS-PAGE | ≥95% |
| Purity by | ≥95% |
| Endotoxin Level | <1 EU/μg by LAL method |
| Biological Activity | >1000 mU (1U = 1 µmole/min/mg) as determined by Cathepsin S Activity Assay Kit (K144-100). |
| Amino Acid Sequence | QLHKDPTLDHHWHLW KKTYGKQYKEKNEEA VRRLIWEKNLKFVMLH NLEHSMGMHSYDLGM NHLGDMTSEEVMSLM SSLRVPSQWQRNITYK SNPNWILPDSVDWRE KGCVTEVKYQGSCGA CWAFSAVGALEAQLK LKTGKLVSLSAQNLVD CSTEKYGNKGCNGGF MTTAFQYIIDNKGIDSD ASYPYKAMDQKCQYDSK YRAATCSKYTELPYGRED VLKEAVANKGPVSVGVD ARH |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease (AD) and Down Syndrome (DS).
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