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Product Details
| Cat # +Size | 7409-10 |
|---|---|
| Size | 10 μg |
| Alternate Name | CTSD, Cathepsin D, CPSD, CLN10 |
| Gene Symbol | CTSD |
| Gene ID | 1509 |
| Accession # | P07339 |
| Source | HEK293 cells |
| Appearance | Liquid |
| Physical Form Description | Supplied as 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, pH 5.5. |
| Molecular Weight | 43.6 kDa (6-His tag at the C-terminus) |
| Purity by SDS-PAGE | ≥ 95% |
| Endotoxin Level | <1 EU/μg by LAL method |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Cathepsin D is also known as CTSD, CPSD, which belongs to the peptidase A1 family. Cathepsin D can be cleaved into the following 2 chains: cathepsin D light chain and cathepsin D heavy chain, which is expressed in the aorta extracellular space (at protein level). The catalytic activity of Cathepsin D is specificity similar to, but narrower than, that of pepsin A. Cathepsin D does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. Cathepsin D involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
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