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Human CellExp™ C-reactive/CRP, Human Recombinant

Binds to phosphocholine expressed on the surface of dead or dying cells
Catalog #: 7242
$150.00

Product Details

Cat # +Size 7242-100
Size 100 μg
Alternate Name CRP, PTX1, C-reactive protein
Gene Symbol CRP
Gene ID 1401
Accession # P02741
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight 24 kDa (6×His tag at the C-terminus)
Purity by ≥95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino Acid Sequence Phe 17 – Pro 224
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

C-reactive protein (CRP) displays several functions associated with host defense including promotion of agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. It also interacts with DNA and histones and may scavenge nuclear material released from damaged circulating cells. CRP binds to phosphocholine on microbes and damaged cells and enhances phagocytosis by macrophages. Therefore, CRP participates in the clearance of necrotic and apoptotic cells. It has been shown that high levels of CRP in humans are associated with an increased risk of cardiovascular diseases. CRP is a beneficial inflammatory biomarker as it is detected much faster than other markers in the blood. Studies have also demonstrated the value of CRP in predicting the development of heart failure and long-term clinical outcomes.


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