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Product Details
| Alternate Name | Osteogenic Protein 1, BMP-7 |
|---|---|
| Gene Symbol | BMP7 |
| Gene ID | 655 |
| Accession # | P18075 |
| Source | Human 293 cell expressed |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl. |
| Molecular Weight | 30 to 38 kDa, homodimer, glycosylated. |
| Purity by SDS-PAGE | ≥95% |
| Endotoxin Level | < 1.0 EU per 1 μg of protein |
| Biological Activity | ED₅₀ is typically 50 to 250 ng/mL. The specific activity was determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line). |
| Reconstitution Instructions | Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
BMP7 belongs to the transforming growth factor-beta (TGFβ) superfamily. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. Based on its expression early in embryogenesis, BMP-7 has a proposed role in early development. In addition, the fact that BMP-7 is closely related to BMP5 has led to speculation of possible bone inductive activity.
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