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Human CellExp™ BMP-7, Human Recombinant

A protein involved in the transformation of mesenchymal cells into bone and cartilage
Catalog #: 6446
SKU-Size Size Price Qty
6446-10 10 μg
$340.00
6446-50 50 μg
$1,240.00
More Sizes Get Quote

Product Details

Alternate Name Osteogenic Protein 1, BMP-7
Gene Symbol BMP7
Gene ID 655
Accession # P18075
Source Human 293 cell expressed
Appearance Lyophilized
Physical Form Description Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.
Molecular Weight 30 to 38 kDa, homodimer, glycosylated.
Purity by SDS-PAGE ≥95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity ED₅₀ is typically 50 to 250 ng/mL. The specific activity was determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).
Reconstitution Instructions Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

BMP7 belongs to the transforming growth factor-beta (TGFβ) superfamily. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. Based on its expression early in embryogenesis, BMP-7 has a proposed role in early development. In addition, the fact that BMP-7 is closely related to BMP5 has led to speculation of possible bone inductive activity.


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