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Human CellExp™ BMP-4, Human Recombinant

A protein involved in bone and cartilage development
Catalog #: 6445

In stock

SKU-Size Size Price Qty
6445-10 10 μg
$305.00
6445-50 50 μg
$1,180.00
More Sizes Get Quote

Product Details

Alternate Name BMP4, ZYME, BMP2B, BMP2B1
Gene Symbol BMP4
Gene ID 652
Accession # P12644
Source Human 293 cell expressed
Appearance Lyophilized
Physical Form Description Lyophilized from a PBS solution.
Molecular Weight 34 kDa, homodimer, glycosylated.
Purity by SDS-PAGE ≥95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity ED₅₀ is typically 2 to 10 ng/mL. The specific activity was determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).
Reconstitution Instructions Reconstitute in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

BMP4 belongs to the transforming growth factor-beta (TGFβ) superfamily. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-4 plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.


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