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Human CellExp™ BMP-2, Human Recombinant

A protein involved in the hedgehog and TGF beta signaling pathway
Catalog #: 6444
SKU-Size Size Price Qty
6444-10 10 μg
$320.00
6444-50 50 μg
$1,180.00
More Sizes Get Quote

Product Details

Alternate Name BMP-2, BMP2A
Gene Symbol BMP2
Gene ID 650
Accession # P12643
Source Human 293 cell expressed
Appearance Lyophilized
Physical Form Description Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.
Molecular Weight 30 to 38 kDa, homodimer, glycosylated.
Purity by SDS-PAGE ≥95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity ED₅₀ is typically 20 to 100 ng/mL. The specific activity was determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).
Reconstitution Instructions Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

BMP2 belongs to the transforming growth factor-beta (TGFβ) superfamily. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. BioVision’s BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.


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