Human CellExp™ Biotinylated CD28, Human Recombinant

Involved in T-cell activation and survival
Catalog #: P1669 | abID:

Product Details

Alternate Name T-cell-specific surface glycoprotein CD28; CD antigen: TP44; Tp44; T-Cell-Specific Surface Glycoprotein; CD28 Molecule
Gene ID 940
Accession # P10747
Source HEK 293 cells
Appearance Lyophilized protein
Physical Form Description Lyophilized powder
Molecular Weight ~42 kDa (Human Fc Tag fused to C-terminus, Biotinylated)
Purity by SDS-PAGE > 95%
Formulation Lyophilized from 0.22µm filtered solution in PBS (pH 7.4) with 5% Trehalose
Amino Acid Sequence Asn 19 - Pro 152
Specific Activity Biotinylated human CD28-Fc can bind to immobilized Human CD80, Fc Tag (Cat. No. P1668 coated at 1 µg/mL, 100 µL/well) with a linear range 0.01 – 0.27µg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Human CD28 is composed of four exons encoding a protein of 220 amino acids that is expressed on the cell surface as a glycosylated, disulfide-linked homodimer of 44 kDa. Members of the CD28 family share a number of common features. These receptors consist of paired V-set immunoglobulin superfamily (IgSF) domains attached to single transmembrane domains and cytoplasmic domains that contain critical signaling motifs. The CD28 and CTLA4 ligands, CD80 and CD86, consist of single V-set and C1-set IgSF domains. The interaction of these costimulatory receptors with ligands is mediated through the MYPPPY motif within the receptor V-set domains. CD28 is expressed constitutively on almost all human CD4 T cells and approximately 50% of CD8 T cells. CD28 costimulation has diverse effects on T cell function, including biochemical events at the immunological synapse, downstream phosphorylation and other post-translational modifications, transcriptional changes, and cytoskeletal remodeling. At the most basic level, CD28 signals increase a cell’s glycolytic rate, allowing cells to generate the energy necessary for growth and proliferation.

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