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Human CellExp™ Beta-NGF, Human Recombinant

A factor critical for the survival & maintenance of sympathetic and sensory neurons
Catalog #: 6443

In stock

SKU-Size Size Price Qty
6443-10 10 μg
$215.00
6443-50 50 μg
$730.00
More Sizes Get Quote

Product Details

Alternate Name Beta Polypeptide, NGF, NGFB, HSAN5, Beta-NGF, MGC161426, MGC161428
Gene Symbol NGF
Gene ID 4803
Accession # P01138
Source Human cell expressed
Appearance Lyophilized
Physical Form Description Lyophilized from a PBS solution.
Molecular Weight 13 kDa, non-disulfide bonded homodimer, non-glycosylated.
Purity by SDS-PAGE ≥95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity ED₅₀ is typically 1.5 to 8 ng/mL. The specific activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
Reconstitution Instructions Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

NGF-beta has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. The presence of beta NGF in immune cells and endocrine cells as well as in the CNS limbic areas suggests that beta NGF may function as an intracellular messenger to regulate the body’s response to stress. This product is produced in a human cell expression system with serum-free, chemically defined media.


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