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Human CellExp™ BAFFR / TNFRSF13C, Fc Tag Human Recombinant

Promotes the survival of mature B-cells and the B-cell response
Catalog #: P1170
SKU-Size Size Price Qty
P1170-10 10 μg
$95.00
P1170-50 50 μg
$385.00
More Sizes Get Quote

Product Details

Alternate Name BAFFR, TNFRSF13C, BAFF-R, BROMIX, CD268, CVID4, prolixin
Gene Symbol TNFRSF13C
Gene ID 115650
Accession # Q96RJ3
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.
Molecular Weight 33.2 kDa
Purity by > 95%
Endotoxin Level < 1.0 EU per/μg
Biological Activity Immobilized Human BAFF, His Tag at 5 μg/mL (100 μL/well) can bind Human BAFFR, Fc Tag with a linear range of 2-31 ng/mL
Reconstitution Instructions Reconstitute in sterile deionized water to a concentration up to 0.2 mg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.


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