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Human CellExp™ B7-H6, human recombinant

Triggers NCR3-dependent natural killer cell activation.
Catalog #: P1013
SKU-Size Size Price Qty
P1013-10 10 µg
$145.00
P1013-50 50 µg
$395.00
More Sizes Get Quote

Product Details

Alternate Name B7-H6, Natural cytotoxicity triggering receptor 3 ligand 1, B7H6, B7 homolog 6, NCR3LG1
Gene Symbol NCR3LG1
Gene ID 374383
Accession # Q68D85
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.2μm-filtered solution in PBS.
Molecular Weight 80 kDa
Purity by SDS-PAGE ≥ 98%
Endotoxin Level < 5 EU/mg
Reconstitution Instructions Reconstitute in 1X PBS to the desired protein concentration.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

B7-H6 is a glycosylated member of the B7 family of immune costimulatory proteins. Orthologs in mouse and rat have not been identified. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30-dependent cell lysis.


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