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Human CellExp™ B7-H3 / CD276, Mouse recombinant

Regulate the T-cell-mediated immune response and a protective role in tumor cells by inhibiting natural-killer mediated cell lysis. Marker for detection of neuroblastoma cells.
Catalog #: P1073
SKU-Size Size Price Qty
P1073-10 10 µg
$85.00
P1073-50 50 µg
$375.00
More Sizes Get Quote

Product Details

Alternate Name B7-H3, CD276, B7 homolog 3
Gene Symbol CD276
Gene ID 102657
Accession # Q8VE98
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
Molecular Weight 25.4 kDa
Purity by SDS-PAGE >95%
Endotoxin Level < 1 EU/μg
Reconstitution Instructions Reconstitute in sterile deionized water to a concentration of 50 μg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.


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