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Product Details
| Alternate Name | B7-H3, CD276, B7 homolog 3 |
|---|---|
| Gene Symbol | CD276 |
| Gene ID | 80381 |
| Accession # | Q5ZPR3-2 |
| Source | HEK 293 cells |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized |
| Molecular Weight | This protein is fused with a Fc tag at C-terminus and has a calculated MW of 50 kDa. |
| Purity by SDS-PAGE | >95% |
| Purity by | >95% |
| Endotoxin Level | < 1 EU/μg |
| Reconstitution Instructions | Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.
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