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Human CellExp™ B7-2 /CD86, human recombinant

Involved in innate immune responses by activating NF-κB-signaling pathway
Catalog #: 7496
SKU-Size Size Price Qty
7496-10 10 μg
$175.00
7496-50 50 μg
$575.00
More Sizes Get Quote

Product Details

Alternate Name CD86, B7-2, B70, CD28LG2, LAB72, MGC34413
Gene Symbol CD86
Gene ID 942
Accession # P42081
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Molecular Weight 26.8 kDa
Purity by SDS-PAGE ≥95%
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized human CD28 at 5 μg/ml (100 μl/well) can bind human biotinylated CD86 with a linear range of 0.08 – 1.25 ug/ml.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in distilled water
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.


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