Product Details
| Alternate Name | T-lymphocyte activation antigen CD80; B7-1; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7 |
|---|---|
| Gene ID | 941 |
| Accession # | P33681 |
| Source | HEK 293 cells |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized powder |
| Molecular Weight | 50 kDa, calculated (with human Fc Tag fused to C-terminus) |
| Purity by SDS-PAGE | > 95% |
| Formulation | Lyophilized from 0.22 µm filtered solution in PBS (pH 7.4) with 5% trehalose |
| Reconstitution Instructions | Reconstitute in sterile PBS, pH 7.4. Do not vortex. |
| Specific Activity | Human biotinylated CD28, Fc Tag (BioVision Cat. No. 9237) can bind to immobilized human CD80, Fc Tag at 1 µg/mL, 100 µL/well with a linear range of 0.01 – 0.27 µg/mL |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
B-lymphocyte activation antigen B7, also known as B7-1 and Cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 and CD86 (B7-2), together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T and Bcell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to CD80 and CD86 with a 20 to 100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. CD80 works in tandem with CD86 to prime T cells and plays a role in induction of innate immune responses by activating NF-κB signaling pathway in macrophages. Additionally, the up-regulation of CD80 has been linked to various autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus and sepsis. CD80 is thus regarded as a promising therapeutic target for autoimmune diseases and various carcinomas.
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