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Human CellExp™ B7-1 / CD80, Cynomolgus Recombinant

Plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages
Catalog #: P1260

In stock

SKU-Size Size Price Qty
P1260-10 10 μg
$105.00
P1260-50 50 μg
$325.00
More Sizes Get Quote

Product Details

Alternate Name CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Gene Symbol CD80
Gene ID 102140078
Accession # G7NXN7
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Purity by SDS-PAGE ≥95%
Purity by ≥90%
Endotoxin Level < 1.0 EU per/μg
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile deionized water.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

B7-1 and B7-2, together with their receptors CD28 and CTLA­4, constitute one of the dominant co-stimulatory pathways that regulate T­ and B­cell responses. Although both CTLA­4 and CD28 can bind to the same ligands, CTLA­4 binds to B7­1 and B7­2 with a 20 ­ 100 fold higher affinity than CD28 and is involved in the down­regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.


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